For centuries, there have been claims that healthy food garnished with exotic spices and condiments provides vital nutrients that help ward off diseases, especially preventable diseases such as diabetes and heart disease (hypertension, coronary artery disease) and promote longevity. The purpose of writing this book is to update the public about the health benefits of ingredients (phytochemicals) in spices and healthy food using existing scientific evidence. The ultimate proof of health benefits will be deciphered by the isolation and identification of specific phytochemicals acting on specific receptors in the body exerting their biological effects. The important point being emphasized is that if the physiological effect of an ingredient is glaring, it is considered to elicit a significant response. However, when the effect of an ingredient is significant, yet the effect is not readily perceivable then the usefulness goes unnoticed and can be questioned as a myth. For example, coffee has several ingredients, but only caffeine acting on the adenosine receptors stimulates the central nervous system and promotes wakefulness. Similarly, the specific active ingredient in hot chili pepper, capsaicin, activates a member of a recently identified family of receptors called transient receptor potential (TRP) channels. TRP vanilloid 1 (TRPV1), which is involved in certain modalities of pain, promotes the release of hormones in the gastrointestinal (GI) tract. Although, the bioavailability of the active ingredients is low, it is important to realize that these ingredients can cause significant local effects in the GI tract by preventing cholesterol regeneration by subduing microbiota, inhibiting precancerous growth by promoting calcium influx and stimulating nerve endings to transmit information and to release of gut hormones that are involved in regulating a variety of functions including appetite and satiety.
This issue of Orthopedic Clinics will cover controversies in fracture care. Orthopedic fractures are a common daily acute health issue and this issue will include everything from timing of debridement in open fracture treatment, to use of bone graft substitutes.
Covering general biology and every aspect of farming freshwater prawns, from current research to development and commercial practice, this has become widely viewed as a landmark publication in the field. The well-known team of editors, New, Valenti, Tidwell, D’Abramo and Kutty, have gathered cutting-edge contributions from the world's leading experts to provide farm personnel, business managers, researchers and invertebrate, freshwater and crustacean biologists with an essential resource.
This monograph presents a new and fundamental approach to software analysis that will provide a source of ideas and inspiration for many years to come. It constitutes a thoroughly revised and extended version of the author's PhD thesis, which was selected as the winning thesis of the 2005 ACM Doctoral Dissertation Competition. Ben Liblit did his PhD work at the University of California, Berkeley, with Alexander Aiken as thesis adviser.
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.
Comprehensive Supramolecular Chemistry II, Second Edition is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996
Soon after neurosurgery had advanced past the stage of that older neurosurgeons will consider their cra removing lesions on the surface of the brain, it became niotomies quite adequate for the relief of many neu apparent that subcortical diseased tissue could not be rological disorders that Professor Kandel shows so excised safely by the usual surgical techniques because clearly to be amenable to stereotactic intervention, of the risk of damaging overlying normal structures. there are many lesions that undoubtedly can be reached Various means of reaching deep-seated lesions were more easily and with less risk to life and limb by ster devised, most of which attempted to approach the eotactic than by open procedures. pathological tissue through "silent areas" of the brain. This book is not just a description of operative However, these operations often resulted in serious procedures, although it does give clear accounts of neurological deficits. Spiegel and Wycis's modifica surgical techniques. It presents the postoperative histo tion of the Horsley-Clarke apparatus to reach targets ries of patients who have been cured or markedly re deep in the human brain introduced a new approach to lieved of longstanding afflictions; these persons have subcortical surgery. True, as Professor Edward Kandel been followed for 10 to 15 or more years, so that the relates, Russian surgeons had pioneered in the field, results may be considered more or less permanent.
TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them
Antioxidants in Food, Vitamins and Supplements bridges the gap between books aimed at consumers and technical volumes written for investigators in antioxidant research. It explores the role of oxidative stress in the pathophysiology of various diseases as well as antioxidant foods, vitamins, and all antioxidant supplements, including herbal supplements. It offers healthcare professionals a rich resource of key clinical information and basic scientific explanations relevant to the development and prevention of specific diseases. The book is written at an intermediate level, and can be easily understood by readers with a college level chemistry and biology background. Covers both oxidative stress-induced diseases as well as antioxidant-rich foods (not the chemistry of antioxidants) Contains easy-to-read tables and figures for quick reference information on antioxidant foods and vitamins Includes a glycemic index and a table of ORAC values of various fruits and vegetables for clinicians to easily make recommendations to patients
This book continues as volume 5 of a multicompendium on Edible Medicinal and Non-Medicinal Plants. It covers edible fruits/seeds used fresh, cooked or processed as vegetables, cereals, spices, stimulant, edible oils and beverages. It covers selected species from the following families: Apiaceae, Brassicaceae, Chenopodiaceae, Cunoniaceae, Lythraceae, Papaveraceae, Poaceae, Polygalaceae, Polygonaceae, Proteaceae, Ranunculaceae, Rhamnaceae, Rubiaceae, Salicaceae, Santalaceae, Xanthorrhoeaceae and Zingiberaceae. This work will be of significant interest to scientists, medical practitioners, pharmacologists, ethnobotanists, horticulturists, food nutritionists, botanists, agriculturists, conservationists, lecturers, students and the general public. Topics covered include: taxonomy; common/English and vernacular names; origin and distribution; agroecology; edible plant parts and uses; botany; nutritive/pharmacological properties, medicinal uses, nonedible uses; and selected references.
Up to 35% of adults suffer from chronic pain, and a substantial number of these patients are admitted to hospitals every year. A major concern of these patients is whether the pain will be adequately controlled during hospitalization. these patients are more likely to have poor pain control and may experience an exacerbation of their co-exisitng chronic pain condition during hospital admission. Adequate pain control is directly related to clinical outcomes, length of hospital stay, and patient satisfaction. A considerable body of evidence demonstrates the medical, social, and economic benefits of satisfactory inpatient pain control. Currently, there are limited pain control guidelines to address this challenging inpatient population. In fact, there are no guidelines outlinign best practices for postoperative pain control in patients with chronic pain. The complex nature of chronic pain and a dearth of publications addressing the concerns of these patients make the creation of relevant guidelines difficult. The goal of this book is to equip clinicians to provide safe and effective management of hospitalized patients with co-existing chronic pain. Each chapter addresses a particular clinical question and is written by an expert in the field. Chapters describe basic principles and specific clinical situations commonly encountered during the care of patients with co-existing chronic pain in hospital settings.
This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
This book is proof that debugging has graduated from a black art to a systematic discipline. It demystifies one of the toughest aspects of software programming, showing clearly how to discover what caused software failures, and fix them with minimal muss and fuss. The fully updated second edition includes 100+ pages of new material, including new chapters on Verifying Code, Predicting Erors, and Preventing Errors. Cutting-edge tools such as FindBUGS and AGITAR are explained, techniques from integrated environments like Jazz.net are highlighted, and all-new demos with ESC/Java and Spec#, Eclipse and Mozilla are included. This complete and pragmatic overview of debugging is authored by Andreas Zeller, the talented researcher who developed the GNU Data Display Debugger(DDD), a tool that over 250,000 professionals use to visualize the data structures of programs while they are running. Unlike other books on debugging, Zeller's text is product agnostic, appropriate for all programming languages and skill levels. The book explains best practices ranging from systematically tracking error reports, to observing symptoms, reproducing errors, and correcting defects. It covers a wide range of tools and techniques from hands-on observation to fully automated diagnoses, and also explores the author's innovative techniques for isolating minimal input to reproduce an error and for tracking cause and effect through a program. It even includes instructions on how to create automated debugging tools. The text includes exercises and extensive references for further study, and a companion website with source code for all examples and additional debugging resources is available. *The new edition of this award-winning productivity-booster is for any developer who has ever been frustrated by elusive bugs *Brand new chapters demonstrate cutting-edge debugging techniques and tools, enabling readers to put the latest time-saving developments to work for them *Learn by doing. New exercises and detailed examples focus on emerging tools, languages and environments, including AGITAR, FindBUGS, Python and Eclipse.
This book is the result of the 11 th International Conference on Information Systems Development -Methods and Tools, Theory and Practice, held in Riga, Latvia, September 12-14,2002. The purpose of this conference was to address issues facing academia and industry when specifying, developing, managing, reengineering and improving information systems. Recently many new concepts and approaches have emerged in the Information Systems Development (ISD) field. Various theories, methodologies, methods and tools available to system developers also created new problems, such as choosing the most effective approach for a specific task, or solving problems of advanced technology integration into information systems. This conference provides a meeting place for ISD researchers and practitioners from Eastern and Western Europe as well as from other parts of the world. Main objectives of this conference are to share scientific knowledge and interests and to establish strong professional ties among the participants. The 11th International Conference on Information Systems Development (ISD'02) continues the tradition started with the first Polish-Scandinavian Seminar on Current Trends in Information Systems Development Methodologies, held in Gdansk, Poland in 1988. Through the years this Seminar has evolved into the International Conference on Information Systems Development. ISD'02 is the first ISD conference held in Eastern Europe, namely, in Latvia, one of the three Baltic countries.
The overall mission of this book is to provide a comprehensive understanding and coverage of the various theories and models used in IS research. Specifically, it aims to focus on the following key objectives: To describe the various theories and models applicable to studying IS/IT management issues. To outline and describe, for each of the various theories and models, independent and dependent constructs, reference discipline/originating area, originating author(s), seminal articles, level of analysis (i.e. firm, individual, industry) and links with other theories. To provide a critical review/meta-analysis of IS/IT management articles that have used a particular theory/model. To discuss how a theory can be used to better understand how information systems can be effectively deployed in today’s digital world. This book contributes to our understanding of a number of theories and models. The theoretical contribution of this book is that it analyzes and synthesizes the relevant literature in order to enhance knowledge of IS theories and models from various perspectives. To cater to the information needs of a diverse spectrum of readers, this book is structured into two volumes, with each volume further broken down into two sections. The first section of Volume 1 presents detailed descriptions of a set of theories centered around the IS lifecycle, including the Success Model, Technology Acceptance Model, User Resistance Theories, and four others. The second section of Volume 1 contains strategic and economic theories, including a Resource-Based View, Theory of Slack Resources, Portfolio Theory, Discrepancy Theory Models, and eleven others. The first section of Volume 2 concerns socio-psychological theories. These include Personal Construct Theory, Psychological Ownership, Transactive Memory, Language-Action Approach, and nine others. The second section of Volume 2 deals with methodological theories, including Critical Realism, Grounded Theory, Narrative Inquiry, Work System Method, and four others. Together, these theories provide a rich tapestry of knowledge around the use of theory in IS research. Since most of these theories are from contributing disciplines, they provide a window into the world of external thought leadership.
Written by an internationally well-known editor team, Endometriosis: Science and Practice is a state-of-the-art guide to this surprisingly common disease. While no cause for endometriosis has been determined, information of recent developments are outlined in this text, offering insight to improve management of symptoms medically or surgically. The first of its kind, this major textbook integrates scientific and clinical understanding of this painful disease helping to provide better patient care.
A Healthy Society offers a new approach to politics – and a new approach to building a healthier world. Dr. Meili argues that health delivery too often focuses on treatment of immediate causes and ignores fundamental conditions that lead to poor health, such as income, education, employment, housing, and environment. This updated edition explores the positive steps that have been taken since publication of the first edition, and includes expanded discussions of basic income, poverty reduction strategies, innovative housing polices, carbon pricing, and the role of health professionals in working for health equity. This book breaks important ground, showing us how a focus on health can change Canadian politics for the better.
Praise for previous editions: I am sure that this second edition of Principles and Practice of Pediatric Neurosurgery will continue to be the standard text for residents, consultants, and attendings the world over.-- Journal of Neurosurgery Lavishly illustrated and eminently readable, this book should find a place in every pediatric neurosurgeons library. Pediatric Neurosurgery Principles and Practice of Pediatric Neurosurgery, Third Edition is a completely revised edition of the most authoritative guide to the management of pediatric neurosurgical disorders encountered in clinical practice. Written by leaders in the field, it provides pediatric neurosurgeons with a clear understanding of the current standards of practice and treatment in the subspecialty. Key Features: Now in full color, with more than 1,000 images An increased emphasis on clinical management strategies in pediatric neurosurgery Seven new chapter topics, including cellular therapy for pediatric neurosurgical disease, conjoined twins, lipomeningoceles, and skeletal syndromes Pearls and pitfalls in every chapter This book is an essential reference for all residents and practitioners in pediatric neurosurgery and pediatric neurology.
This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
This book constitutes revised selected papers from the International Conference on Advanced Computing, Networking and Security, ADCONS 2011, held in Surathkal, India, in December 2011. The 73 papers included in this book were carefully reviewed and selected from 289 submissions. The papers are organized in topical sections on distributed computing, image processing, pattern recognition, applied algorithms, wireless networking, sensor networks, network infrastructure, cryptography, Web security, and application security.
Robotic Urologic Surgery is a technical manual for various robotic approaches to surgical procedures, with helpful hints for avoiding pitfalls. The book shows how to develop a successful robotics program, learn the various techniques, and improve outcomes. Leading robotic urologic surgeons worldwide contribute chapters. The body of available data is reviewed in table format and supported by schematic diagrams and anatomic photographs to illustrate the concept being discussed. An accompanying DVD gives instructional content. This book is essential reading for all urologists as a reference to establish a robotics program, refine their surgical technique and provide information to patients.
Based on the 38th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Ascona, Switzerland in July 2010, this volume covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.
Lipids have been in clinical use as components of intravenous nutrition for over 50 years. Over the last 15 years, new and improved lipids that include olive oil and/or fish oil have replaced the more traditional ones. These new lipids offer the opportunity to deliver high amounts of fatty acids and possess different functional properties: in particular, they can influence inflammatory processes, immune responses and hepatic metabolism. This book brings together articles written by leading international authorities in the area of intravenous lipids. Contributions discuss the latest findings in the field, ranging from pre-clinical research to the most recent clinical trials. Lipid functionality and utility in pediatric, adult surgical and critically ill patients are covered, as is the use of lipids in long-term home parenteral nutrition. Addressing a broad spectrum of topics, this publication provides a wealth of information for basic scientists, clinical researchers and clinical practitioners alike.
Advanced Practice in Healthcare outlines the key components of advanced practice in which healthcare professionals are engaged. With a clear skills focus, it explores issues critical to providing effective enhanced care to patients whilst managing and negotiating the complexities of the healthcare delivery system. Perspectives on advanced practice are illuminated throughout the text and are designed to promote the formation of new thinking in relation to practice, education and research. The text is comprised of three sections that address different aspects of advanced practice and these in turn: Provide guidance on the development of clinical skills, including consultation, clinical decision making, holistic care, and the role of care planning in advanced practice. Explain management skills and how to manage, negotiate and monitor the complexities of the healthcare system in order to ensure the delivery of quality patient care. Clarify the professional role of the advanced practice clinician and how implementation of the role can improve the delivery of patient care. In each chapter activities are presented that assist in the development, implementation and extension of advanced level practice. This text is especially relevant to nurses, midwives and allied health professionals practising within primary and secondary care who wish to advance their practice or clarify their roles within the context of advanced practice, particularly those undertaking masters level study.
Filling the gap for a book that covers not only plasma in gases but also in liquids, this is all set to become the standard reference for this topic. It provides a broad-based overview of plasma-chemical and plasmacatalytic processes generated by electrical discharges in gases, liquids and gas/liquid environments in both fundamental and applied aspects by focusing on their environmental and green applications and also taking into account their practical and economic viability. With the topics addressed by an international group of major experts, this is a must-have for scientists, engineers, students and postdoctoral researchers specializing in this field.
Rajkumar is a young orphan helping out in a market stall in the dusty square outside the royal palace in Mandalay, when the British force the Burmese King, Queen and court into exile. Haunted by his vision of the Royal Family and one of their attendants, he travels to the obscure town where they have been exiled, and his family and friends become inexorably linked with theirs. From this humble beginning, an extraordinary story of a century unfolds: in Malaya, amid the vast rubber plantations; in India, amid growing nationalistic fervor; in America, where ideals of democracy, terrorist skills and business acumen could all be learned. By the time World War II arrives, Rajkumar's influence will have spread from the great estate at Morningside and he will see his son become involved in the British collapse in Singapore, and another member of his family take part in the remarkable rebellion of the Indian troops against their British officers. Many more fascinating stories unfold in the pages of The Glass Palace. There is the formidable Indian widow, Uma, a spearhead of the Indian nationalist movement and a final refuge for the battered remnants of the family as they flee from Burma before the Japanese advance. And there is Rajkumar's granddaughter, who survives the experience and brings readers back to Burma, completing the family saga started so long ago.
Nanocatalysis has emerged as a field at the interface between homogeneous and heterogeneous catalysis and offers unique solutions to the demanding requirements for catalyst improvement. Heterogeneous catalysis represents one of the oldest commercial applications of nanoscience and nanoparticles of metals, semiconductors, oxides, and other compounds have been widely used for important chemical reactions. The main focus of this fi eld is the development of well-defined catalysts, which may include both metal nanoparticles and a nanomaterial as the support. These nanocatalysts should display the benefits of both homogenous and heterogeneous catalysts, such as high efficiency and selectivity, stability and easy recovery/recycling. The concept of nanocatalysis is outlined in this book and, in particular, it provides a comprehensive overview of the science of colloidal nanoparticles. A broad range of topics, from the fundamentals to applications in catalysis, are covered, without excluding micelles, nanoparticles in ionic liquids, dendrimers, nanotubes, and nanooxides, as well as modeling, and the characterization of nanocatalysts, making it an indispensable reference for both researchers at universities and professionals in industry.
Erythropoietin, Volume 105, the latest release in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. Topics covered in this new volume include Erythropoietin Receptor Structural Domains, Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists, Endogenous Erythropoietin, Erythropoietin Receptor Signaling and Lipid Rafts, and Erythropoietin and Hypothalamic-Pituitary Axis. Each thoroughly reviewed volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors and others. This volume documents the activities of this vital molecule, also describing the structure and function of erythropoietin and its receptor. Presents the latest information on erythropoietin Provides a long-running series that focuses on updates and advances in vitamins and hormones Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances
In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.
The challenge of providing adequate power on an indefinite basis without causing long-term damage to the environment requires a versatile means of energy conversion and storage. As such, electrical energy storage is becoming more vital today than at any time in human history. Electrochemical systems, such as batteries, supercapacitors, fuel cells, and photoelectrochemical cells, can help meet this objective. Future generations of rechargeable lithium batteries will be required to power portable electronic devices, store electricity from renewable sources, and serve as a vital component to pursuing electric mobility in the future to reduce fossil fuel demand and mitigate environmental issues. In this context, engineering of new materials, especially at the nanoscale, has become imperative to achieve enhanced energy and power density to meet the future challenges of energy storage. This book outlines the state of the art of nanoscale aspects of advanced energy storage devices, such as lithium-ion batteries, including microbatteries and electrochemical supercapacitors. It focuses on various fundamental issues related to device performance of various positive and negative electrode materials, with special reference to their nanoscale advantages. It also includes fundamentals and processing techniques with regard to synthesis, characterization, physical, and electrochemical properties, and applications of nanoscale materials pertaining to advanced electrochemical power sources. A variety of advanced nanomaterials, such as transition metal oxides, phosphates, silicates, and conversion electrodes, together with some special nanomaterials such as carbon nanotubes, nanorods, and mesoporous carbons are discussed by many notable authorities in the field.
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 . However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized . In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.
The second edition of this very successful book provides a practical approach to liver MRI, with coverage of the most up-to-date MR imaging sequences, normal and variant anatomy and diverse pathologic conditions. It features computer-generated drawings relating clinical concepts to the MRI findings, 2D and 3D reconstructions, systematic (differential) diagnostic information and descriptions of patient management options. MRI findings are correlated to ultrasound, computed tomography, nuclear medicine exams, laboratory findings and histopathology when appropriate. New information is presented on a wide range of topics and more than 50 extra figure pages are included. This book will greatly benefit all professionals interested and involved in imaging, diagnosis and treatment of focal and diffuse liver lesions, including radiologists, gastroenterologists, hepatologists, surgeons, pathologists, MR physicists, radiology and other residents, MR technologists and medical students.p>
This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including free radicals, exceeds the body’s natural antioxidant defences, leading to cellular damage. Oxidative stress is present in about half of all infertile men, and reactive oxygen species can produce infertility both by damaging the sperm membrane, with consequences for sperm motility, and by altering the sperm DNA. There is consequently a clear rationale for the use of antioxidant treatments within andrology, and various in vitro and in vivo studies have indicated that many antioxidants indeed have beneficial impacts. In providing a detailed and up-to-date overview of the subject, this book will be of interest to both practitioners and researchers in andrology, endocrinology, and urology.
In The Night Shift, Dr. Brian Goldman shares his experiences in the witching hours at Mount Sinai Hospital in downtown Toronto. We meet the kinds of patients who walk into an E.R. after midnight: late-night revellers injured on their way home after last call, teens assaulted in the streets by other teens and a woman who punches another woman out of jealousy over a man. But Goldman also reveals the emotional, heartbreaking side of everyday E.R. visits: adult children forced to make life and death decisions about critically ill parents, victims of sexual assault, and mentally ill and homeless patients looking for understanding and a quick fix in the twenty-four-hour waiting room. Written with Goldman’s trademark honesty and with surprising humour, The Night Shift is also a frank look at many issues facing the medical profession today, and it offers a highly compelling inside view into an often shrouded world.